Glutathione, Methylation & Nutrition w/ Dr. Russell Jaffe

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Episode #56: Russell Jaffe, MD PhD – Glutathione, Metallothionein and Vitamin C: key detox molecules

Dr. Jaffe shares his top tips to increase glutathione, metallothionein and methylation.

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————————————–Key Takeaways———————————-

06:27 The Power of Epigenetics: We have shifted from a focus on metabolism and biochemical individuality, to epigenetics – your lifestyle, habits, and choices regarding what you eat, drink, think and do determines 92% of your lifetime health that is not genetic. A small fraction of our health is determined by our DNA and our genes.

08:30 Effects of Toxins: It is your internal adaptations that determine the effect that toxins will have on you. For example: toxic metals can be a serious problem, but if you have enough healthy metallothionein to take up and detoxify those metals, they do not stay in your body. If you have switched from this elective/protective mode into survival mode, then your body cannot devote the energy to detoxification in order to deal with the immediate crisis.

10:41: How Does Metallothionein Work? Metallothionein is a protein made of two amino acids: glycine and the sulfur-containing cysteine. Metallothionein is a magnesium/zinc rich protein that gives up its magnesium or zinc and irreversibly binds to any of the toxic metals, like mercury or lead. They are then excreted from the body through sweat, stool, or urine. Metallothionein is everywhere in our bodies and is measureable. When we shift to survival mode, toxic metals begin to accumulate. The same happens with persisting pollutants, volatile chemicals and the risk of exposure to radioisotopes or other environmental pollutants.

12:44 How to Upregulate Metallothionein: A diet rich in sulfur foods, you can build metallothionein, if you stay alkaline and you have a balanced nutrient intake, appropriate for your lifestyle. Metallothionein is very important to our long term health and survival. Nutrition begins in the kitchen, in the cooking pot. It begins with whole foods that you consume in as whole a form as possible. GGOBE is an acronym he uses for top sulfur-rich foods. It stands for garlic, ginger, onions, brassica sprouts and eggs.
16:55 Whey Protein: Whey protein is high in cysteine.

19:22 Metallothionein and Glutathione: The purpose of both of these is to protect us. Glutathione is synthesized inside of cells. Oral glutathione may help the gut and the mucosal barrier, but it does not go to your body’s cells. Glutathione is an important intermediary in keeping oxidative stress low. If we give the precursor amino acids for glutathione production in cells, GGOBE foods or supplements that contain cysteine, methionine and we have a healthy alkaline cell with mitochondria are healthy, we can make glutathione.

21:58 Mitochondria and Cell Health:The cell protects the mitochondria and the mitochondria give the cell ATP. The mitochondria also detoxify things like pesticides, persisting pollutants and hormone disruptors. These must be detoxified inside the mitochondria. If the mitochondria are overwhelmed, then the energetics of the cell slows and uses up Coenzyme Q10, which is the electron shuttle, impairing things further. About 66% of our detoxification happens in the liver. Maybe 15% of detox happens in the kidneys. A small percentage takes place in the spleen. Some also happens in our skin. Every muscle, every cell of the body does some detoxification and utilizes mitochondria to do that.

24:50 Ascorbate and Raising Glutathione: Unlike vitamins, ascorbate does not activate catalysts. It is used directly. It is a sub straight. It is used up in the course of detoxifying, energizing and protecting the other antioxidants in the body. Ascorbate is the correct name. It is the mother protective molecule for all other protective molecules in the body. The best way to raise glutathione in the cell is to give ascorbate. The amount of glutathione that you generate is proportional to having enough ascorbate.

27:42 C-Cleanse: Quickly saturate the body with mineral ascorbate, so you have calcium, magnesium, potassium and zinc minerals along with the ascorbate. Toxins and fluid are flushed out of the body. When you have taken in the amount of ascorbate you need to protect from oxidative stress, you are also maximizing the glutathione inside the cells.

45 thoughts on “Glutathione, Methylation & Nutrition w/ Dr. Russell Jaffe

  1. So he essentially says what we already knew, diets high in raw plants are much more protected against oxidative damage and especially DNA damage.

  2. There are WAY more foods high in sulfer than what he's mentioned. All veggies in the allium genus: including but not limited to onion, garlic, chives, shallots, leeks. Also all veggies in the brassicacaea family aka cruciferous veggies including broccoli, cauliflower, collards, cabbage, bok choy, turnip, radish, etc.. Also, most meats have sulfur. Especially crab, chicken, lobster, organ meats, and others. Not sure why his list is so small.

  3. I'm dealing with histamine intolerance, severe brain and cognition problems and I had intution to look up histamine intolerance and methylation and it led me to metalothionein and that led me to this video. I do believe in Jesus Christ and I do pray alot and I just woke up today about an hour ago with this though (which i believe came from God) and led me hear, and I immediatly looked roasted garlic recipe. I have been craving onions and garlics anyways! never knew you could roast a whole bulb! I hope to find healing and thank God my father through Jesus Christ for this all because if not for my faith, i would have ended my life over 20+ times due to such bad spiritual and physical problems the past 36 years i have lived on this earth.

  4. When I was diagnose with stage four bone marrow cancer, I soon after had an intuition to use plenty ginger, both fresh, and ginger powder in my morning smoothie.
    I also ferment garlic in honey. Anyway, I am at 75 years young, and nine years in remission, and in excellent health. I have no need for any pharmaceutical junk medicine. If I did I
    would find a natural way to cure myself.

  5. All you need to do is change your diet to about 70% cooked vegetables. Like he mentions garlic, onion and then brussel sprouts, broccoli, daikon, caulifower, golden beets, celery, etc. But cooked so they are easy to digest. The ideal amount is 6-9 cups every day. Not only just for sulfur, but because you are getting the alkaline reserve minerals in abundance. And then of course you need like 4-5 ounces of meat with every meal. Pretty much that is it. You'll be healthier than ever. It would be even better if you cut out all vegetable oils and stick to coconut oil. And some dairy is fine. I usually get some raw cheese or goat milk. I know this diet doesn't sound appetizing at first, but after a while your taste buds change, and cooked vegetables actually taste really good!

  6. This sounds very complicated, I went through all the various diets, strict vegan for 13 years. Macrobiotic, plant based, omnivore, spent tens of thousands of dollars on various supplements, whey, spirulina, multivitamins, juicing, Made my own sauerkraut did the raw Hippocrates thing for years. Stayed away from red meat for 30 years. Ate garlic and onions til I reeked. Nothing but slow weight gain, a few pounds a year, grey hair started at 23 years old, my teeth started to decay, cavities, and grinding my teeth at night. constipation even though pumping the raw vegetable's, fruit, kraut ect. I am 64 now and went to nothing but animal foods, mainly grass fed meats and organs, bone broth, some raw milk cheeses wild caught fish.. Lost 25 pounds of body fat, gained unbelievable strength, I feel like great mentally, energy is way up. Not concerned about bowel movements. Gas and bloating gone. I feel my colon is starting to heal after all the fiber The only supplements I take now D3, Selenium, Iodine, MSM. cod liver oil.

  7. This video needs to stay up forever!!!!! It has made such a difference in my foggy brain and health. Natural path doctors and these Health Coaches are not trying help poor people , sick people who really need help or sick seniors who are on fix budgets. They charge anywhere from $1000 to $8000 for 1 to 3 months of service. That’s enough to make you sick. I’m on day two of glutathione and vitamin C powder. I only eat what will not disturb my foggy brain or digestion and I feel better than I have after spending over $12,000 any getting no where with my healing. This is a great video!!!!

  8. thank you so so much for this amazing information and some history behind the nutrients, it was refreshing to hear a medical person giving such wonderful advice. very grateful to you all
    love and light


  9. I often daydream about what would have happened if Linus Pauling had lived another 30 years and we had his wisdom today. He would have acquired this kind of understanding that Dr. Jaffe has, coupled with the all the other analytical and pattern memory etc. etc. that made him oen of the greatest experimental scientists of all time. To any physician scientists, qualified or self-taught to that level, reading this, please mention others who you think have reached this level that Dr. Jaffe shows. I would love to have some names to go to.

  10. I have been studying translational medical science for many years. Dr. Jaffe has the best combination of basic deep understanding of chemistry, through biochemistry, through molecular biology and how to apply it to the practicalities of living of any qualified clinician-scientist tfhat I have found so far on the web. My hat is off to you, sir. I can't get enough of your wisdom.

  11. The Ginger Root Lemons and Limes and red peppers to taste with some crushed garlic glove can be blended together with some water or coconut water. Add a date or 2 with a finger size fruit of Thai Tamarind Fruit to mix all together in our blender. Pour the mixture into a large glass mason jar and add more water to the top. Your water must be filtered or boiled rainwater that we use. Place a glass lid or saucer over the mouth of the mason jar . Then place this room-temperature tea outside in your garden for some SUN exposure for a day or two. Then strain the liquid through a straining basket into another jar and refrigerate your probiotic solar herbal tea for Detox and Cleansing a therapy that the Garden Villa Phuket Thai Nature Retreat does on a regular basis. This is a good all-around tonic for your health.

  12. Epigenetics: 92% of your health is determined by your lifestyle health; food you eat, pure water you drink, sleeping well, toxin loads, anger management, forgiveness, mindful living.
    A very small part is genetic according to Dr. Jaffe. Metallothionein is a protein made up of two amino acids (glycene & cysteine) that bind magnesium and zink that attaches to heavy metals through sweat, bowls, etc. the same thing is true for other environmental toxins, ie. volitional chemicals and persistent chemicals and radio isotopes. To stay vital and energetic, stay alkaline, diet rich in sulfur foods to build metallothionein, balanced nutrient intake for your lifestyle. Nutrition begins in kitchen with whole food. GGOBE: garlic, ginger, onions, brassica sprouts and eggs) one or more should be a staple, not a condiment, Eat it as a staple (a lot of it) if you don't you will use up your methylation sources and not be able to replace it. Native whey protein (no casein additives, but using counter flow technique) will build glutathione.@ 17:40. Glutathoine would be built through taking whole foods, NOT oral supplements, this is only partial supplementing. Your body needs to go through the process of eating whole food that get broken down into amino acids and then taken in to the body which at the cellular level which combines it back into glutathoine. Eat GOBBE! So your mitochondria has s healthy proton gradient and the cell is alkaline- your cells can make glutathtione! It can shuttle electrons and protect from oxidative stress, etc. Mitorchondria is the battery that gives the calls ATP and the mitochondria detoxes pesticides and hormone disruptoers INSIDE the mitochondria. If your mitochondria is gummed up, it impairs the cell. WE'RE ONLY HALF WAY THROUGH PEOPLE! DR. JAFFE is AMAZING!!!

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