Glutathione, Methylation & Nutrition w/ Dr. Russell Jaffe

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Episode #56: Russell Jaffe, MD PhD – Glutathione, Metallothionein and Vitamin C: key detox molecules

Dr. Jaffe shares his top tips to increase glutathione, metallothionein and methylation.

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————————————–Key Takeaways———————————-

06:27 The Power of Epigenetics: We have shifted from a focus on metabolism and biochemical individuality, to epigenetics – your lifestyle, habits, and choices regarding what you eat, drink, think and do determines 92% of your lifetime health that is not genetic. A small fraction of our health is determined by our DNA and our genes.

08:30 Effects of Toxins: It is your internal adaptations that determine the effect that toxins will have on you. For example: toxic metals can be a serious problem, but if you have enough healthy metallothionein to take up and detoxify those metals, they do not stay in your body. If you have switched from this elective/protective mode into survival mode, then your body cannot devote the energy to detoxification in order to deal with the immediate crisis.

10:41: How Does Metallothionein Work? Metallothionein is a protein made of two amino acids: glycine and the sulfur-containing cysteine. Metallothionein is a magnesium/zinc rich protein that gives up its magnesium or zinc and irreversibly binds to any of the toxic metals, like mercury or lead. They are then excreted from the body through sweat, stool, or urine. Metallothionein is everywhere in our bodies and is measureable. When we shift to survival mode, toxic metals begin to accumulate. The same happens with persisting pollutants, volatile chemicals and the risk of exposure to radioisotopes or other environmental pollutants.

12:44 How to Upregulate Metallothionein: A diet rich in sulfur foods, you can build metallothionein, if you stay alkaline and you have a balanced nutrient intake, appropriate for your lifestyle. Metallothionein is very important to our long term health and survival. Nutrition begins in the kitchen, in the cooking pot. It begins with whole foods that you consume in as whole a form as possible. GGOBE is an acronym he uses for top sulfur-rich foods. It stands for garlic, ginger, onions, brassica sprouts and eggs.
16:55 Whey Protein: Whey protein is high in cysteine.

19:22 Metallothionein and Glutathione: The purpose of both of these is to protect us. Glutathione is synthesized inside of cells. Oral glutathione may help the gut and the mucosal barrier, but it does not go to your body’s cells. Glutathione is an important intermediary in keeping oxidative stress low. If we give the precursor amino acids for glutathione production in cells, GGOBE foods or supplements that contain cysteine, methionine and we have a healthy alkaline cell with mitochondria are healthy, we can make glutathione.

21:58 Mitochondria and Cell Health:The cell protects the mitochondria and the mitochondria give the cell ATP. The mitochondria also detoxify things like pesticides, persisting pollutants and hormone disruptors. These must be detoxified inside the mitochondria. If the mitochondria are overwhelmed, then the energetics of the cell slows and uses up Coenzyme Q10, which is the electron shuttle, impairing things further. About 66% of our detoxification happens in the liver. Maybe 15% of detox happens in the kidneys. A small percentage takes place in the spleen. Some also happens in our skin. Every muscle, every cell of the body does some detoxification and utilizes mitochondria to do that.

24:50 Ascorbate and Raising Glutathione: Unlike vitamins, ascorbate does not activate catalysts. It is used directly. It is a sub straight. It is used up in the course of detoxifying, energizing and protecting the other antioxidants in the body. Ascorbate is the correct name. It is the mother protective molecule for all other protective molecules in the body. The best way to raise glutathione in the cell is to give ascorbate. The amount of glutathione that you generate is proportional to having enough ascorbate.

27:42 C-Cleanse: Quickly saturate the body with mineral ascorbate, so you have calcium, magnesium, potassium and zinc minerals along with the ascorbate. Toxins and fluid are flushed out of the body. When you have taken in the amount of ascorbate you need to protect from oxidative stress, you are also maximizing the glutathione inside the cells.

Methylation, Fat Adaptation & Your Metabolism w/ Ben Lynch, ND

Gene expert Dr. Ben Lynch helps us to better understand which flavor of genes we have and how that may affect things like food cravings, fat adaptation and hormone metabolism.

Check out Dirty Genes book:

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Show Notes;

If you crave sugar and sweets, it’s not that you’re broken, Dr. Ben says. You may have a flavor of COMT or MAO that influences neurotransmitter breakdown and metabolism.

I think this knowledge is super helpful when it comes to personalizing a diet and exercise program that will work for you in the long term.

Dr. Lynch and I also dive into the methylation cycle and how it is involved in the
synthesis of many key molecules needed to burn fat for fuel

Hope you enjoy the convo.

Show notes and video:

He’s got a great new book out, called Dirty Genes—I posted a quick summary of that, here:

Key Takeaways:

05:21 Methylation occurs in every cell all over the body. In the brain it makes neurotransmitters.
06:23 Carnitine is required during intermittent fasting, ketosis and general fat consumption.
07:39 One sign that you are not methylating well would be an active startle reflex.
09:24 Methylation’s primary job is to turn off genes. It does turn some on.
10:17 Most methyl groups are found in protein. The cobalamins produced by gut bacteria is used only by our gut bacteria.
13:40 Stop taking folic acid.
21:24 Methylation plays a minor but significant role in detoxification.
23:49 Foods to support detoxification include cruciferous vegetables, eggs, and broccoli and radish sprouts eaten together.
27:05 If you are having high reactive nitrogen species or high reactive oxygen species, your attempts at keto will fail.
29:04 If NQO1 is not functioning well, CoQ10, vitamin C, glutathione and vitamin E supplements may do harm.
29:46 High dopamine quinone levels are found in those of us with dementia, neurological disorders, and Parkinson’s. The vitamin needed to run NQO1 is riboflavin.
32:00 Estrogen quinones lead to estrogen sensitive cancers.
32:26 Excessive levels of dopamine in your brain will lead to more norepinephrine and epinephrine.
40:30 If you have a faster COMT, eat more protein and perhaps supplement with more tyrosine.
42:00 Fast COMT/inattentive folks fidget and move to stimulate their brains to make dopamine.
43:37 Slower COMT is associated with PMS, estrogen based cancers, insomnia and higher blood pressures.
50:15 A fast MAOA depletes your serotonin levels and burns through your tryptophan.
56:34 You don’t have to be on a ketogenic diet to burn fat.
01:00:03 Excessive exercise and overtraining causes inflammation, which causes increased blood sugar, which kicks you out of ketosis.
01:03:40 The other Super Seven Genes
01:05:28 Check your arsenic levels.
01:06:20 Stop thinking disease and focus on function.
01:09:35 Every action you take cleans your genes or dirties your genes.
01:10:45 Dr. Lynch’s morning routine is one of personal growth and deep work.
01:16:00 Dr. Lynch’s desert island nutrient is liposomal glutathione.
01:17:05 Dr. Lynch’s elevator pitch: The cure for all conditions is preventing it.

Vitamin D, Deep sleep & Gut Bacteria w/ Dr. Stasha Gominak

Dr. Stasha Gominakdiscusses how vitamin D (from the sun) is needed to improve the stability of gut bacteria, which in turn help synthesize B vitamins necessary to facilitate deep sleep.

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————————————–Key Takeaways———————————-

02:29 Hundreds of Dr. Gominak’s patients, children, teenagers and young healthy females, didn’t have REM sleep.
04:42 Sleep apnea, fibromyalgia, chronic fatigue were not recognized in the 1960s and 1970s, because they were not epidemic.
07:21 Vitamin D and the brain stem are major players in deep sleep.
10:03 You must be paralyzed in order to achieve the proper levels of sleep.
14:21 Why would an 8 year old have more than one sleep disorder?
16:02 There has been a major historical shift from living/working/playing outside.
17:07 Once you replace vitamin D, the body slowly changes from a vitamin D deficient body to a B deficient body.
18:08 While bears hibernate, their microbiome consumes the colonic mucus, which makes all of the B vitamins to meet the bear’s metabolic needs during hibernation. Does ours?
22:05 Why Did It Take 2 Years to Become B Deficient?
23:44 Each B vitamin has an intestinal bacterial source and a food source.
26:02 Wanted: Gut Bugs
31:39 You can fix your own bacteria with vitamin D levels above 40 and take B100 or B50 for 3 months.
32:58 The sodium linked multivitamin transport system pumps 3 vitamins, pantothenic acid, alpha lipoic acid and biotin, into our digestive system and our brain.
36:24 Dr. Gominak sees a correlation between autism and vitamin D deficiency.
38:27 The development of sexual dysmorphism and sleep.
42:34 When a child cannot get out of bed in the morning, this is may be the brain demanding that they go back to sleep to get REM.
44:03 A lack of REM sleep cheats a child of their normal development.
47:15 Children and adults normally make small subtle movements and tiny vocalizations, not talking, walking or falling out of bed.
48:27 Taking the Weston A. Price westernization theory to another level.
56:02 Breastfeeding enlarges nasal passages.
57:28 Dr. Gominak believes that vitamin D is trophic to the bacteria that we are supposed to have in our gut.
59:24 Pantothenic acid not only makes acetylcholine, it makes cortisol.
60:11 Acetylcholine is a chemical used by the vagus nerve.
01:07:46 A test result of pantothenic acid levels will parallel magnesium levels. It tells you what is in the blood, but not what is in the stores.
01:09:10 Perhaps we are completely self-healing with REM sleep.
01:12:26 Dr. Gominak’s Morning Routine
01:13:31 The ketogenic diet helps people to live longer. Being ketogenic during REM sleep helps us repair. We were probably designed to go into ketosis for at least 12 hours every night.
01:15:08 A new theory is that the tricarboxylic acid/CREB cycle, which is used when you are using fats as your energy supply, may have a different purpose. It may not be about making ATP.
0101:19:33 Dr. Gominak’s desert island herb, nutrient or supplement: Her choice is vitamin D, even on a desert island.
01:30:35 Dr. Gominak’s Elevator Pitch: We can impact our children, especially children of color. It they don’t go outside, they don’t make enough vitamin D.